A USMLE Step 1 question bank of exam-style clinical vignettes across the basic sciences, with mechanism-first explanations, timed 40-question blocks that mirror the real test day, and analytics that surface your weakest systems.
What's in the USMLE Step 1 bank
Step 1-style vignettes across every basic science discipline and organ system.
Clinical vignettes written in Step 1 style, testing integrated reasoning rather than recall.
Explanations that start from the mechanism and work through every distractor.
Timed blocks of 20 or 40 questions, matching real test-day pacing.
Smart Revision for flagged items and previously incorrect answers.
Per-system and per-discipline analytics with anonymised peer benchmarking.
Syllabus tutorials for each topic so you can learn then test.
Syllabus coverage
Foundational sciences
Biochemistry and genetics
Microbiology and immunology
Pathology and pathophysiology
Pharmacology
Organ systems
Cardiovascular
Respiratory
Renal and reproductive
Gastrointestinal and endocrine
Neuroscience and behaviour
Neuroanatomy and neurology
Psychiatry and behavioural science
Practice foundations
Biostatistics and epidemiology
Ethics and communication
Patient safety and quality improvement
Sample USMLE Step 1 question
A 24-year-old woman has fatigue and a haemoglobin of 9.6 g/dL with an MCV of 68 fL, low ferritin and a raised platelet count. Which is the single most appropriate next investigation?
A.Bone marrow aspirate
B.Hemoglobin electrophoresis
C.Celiac serology
D.Serum B12 and folate
E.Direct antiglobulin test
Answer: Celiac serology
Iron deficiency in a young woman with no obvious blood loss should prompt a search for malabsorption; celiac disease is the commonest occult cause and tissue transglutaminase antibodies are the first-line test. Electrophoresis addresses thalassemia, which does not lower ferritin.
Frequently asked questions
Are the questions written in real USMLE Step 1 style?
Yes — each item is a clinical vignette requiring integration of basic science with a clinical presentation, in the style of the real exam.
How long are the practice blocks?
Timed blocks of 20 or 40 questions, so you can practise a short set or a full-length block matching test-day pacing.
Is Step 1 pass/fail scoring reflected?
Yes — since 2022 Step 1 is reported as pass/fail, so Examrix focuses on readiness by discipline and system rather than a predicted three-digit score.
Can I try it first?
Yes. There is a 3-day full-access trial with no card required, plus free revision note previews.
